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Why would a body reject an organ transplant?
Rejection is when the organ recipient's immune system recognizes the donor organ as foreign and attempts to eliminate it. It often occurs when your immune system detects things like bacteria or a virus.
Is tacrolimus nephrotoxic?
The molecular basis of cyclosporine and tacrolimus nephrotoxicity is less well understood, but there is evidence that it may be mediated by the calcineurin pathway as well. Thus, cyclosporine and tacrolimus binding proteins are present at a high concentration in the kidney (higher than in the liver and spleen).
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